The Journal of Phytopharmacology 2023; 12(1):1-10 ; DOI:10.31254/phyto.2023.12101
Memory-Enhancing and Antioxidant Activities of the Hydroethanolic Leave Extract of Piliostigma reticulatum (Fabaceae) in the Monosodium Glutamate-Induced Alzheimer's Disease Model
Galba Jean Beppe1 , Bertrand Poo Barga1 , Donatien Albert Atsamo2 , Christ-Roi Fedaski1 , Alice Irène Folefack1 , Nanou Gael Allah-Doum1 , Franklin Gamo Zemo3 , Alain Bertrand Dongmo4
1. Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814 Maroua, Cameroon
2. Department of Animal Biology, and Physiology, University of Yaoundé I, Yaoundé, Cameroon
3. Department of Psychology, Faculty of Arts, Letters and Social Science, University of Yaoundé I, P.O. Box 7011, Yaoundé, Cameroon
4. Department of Animal Biology Faculty of Science University of Douala P.O. Box 24157 Douala, Cameroon
*Author to whom correspondence should be addressed.
Received: 22nd January, 2023 / Accepted: 28th February, 2023
Background: Piliostigma reticulatum (Fabaceae) is a plant used in Cameroon for the treatment of madness and migraine. Aims and Objectives: This study aims to evaluate the memory-enhancing and antioxidant activities of the hydroethanolic leaves extract of PR in the monosodium glutamate-induced Alzheimer's disease model. Materials and Methods: The Y-maze, Radial-arm maze and Novel object recognition tests were used to assess short, and long-term memory. At the end of the experiments, the brains of mice were scavenged for biochemical and histological analysis. Results: It was observed that the hydroalcoholic extract of PR leaf significantly reversed the percentage of spontaneous alternation compared to the negative control group at the different doses tested (p
Reference memory, Working memory, Anticholinesterase, Spontaneous alternation, Alzheimer's disease
HOW TO CITE THIS ARTICLE
Beppe GJ, Barga PB, Atsamo DA, Fedaski CR, Folefack AI, Alla-Doum NG, Gamo FZ, Dongmo AB. Memory-Enhancing and Antioxidant Activities of the Hydroethanolic Leave Extract of Piliostigma reticulatum (Fabaceae) in the Monosodium Glutamate-Induced Alzheimer's Disease Model. J Phytopharmacol 2023; 12(1):1-10. doi: 10.31254/phyto.2023.12101
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